Formic Acid → HCID 178422326, 화합물

HRID 2064634노트

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HRID 2064634 반응식
[Cl:1][C:2]1[C:3]([CH3:10])=[CH:4][C:5]([NH2:9])=[C:6]([NH2:8])[CH:7]=1.[OH-].[NH4+].[CH:13](O)=O>Cl>[Cl:1][C:2]1[C:3]([CH3:10])=[CH:4][C:5]2[N:9]=[CH:13][NH:8][C:6]=2[CH:7]=1

참가 물질

5

반응물 3

HCID 284Formic AcidHCID 14923Ammonium HydroxideHCID 28014684-Chloro-5-methylbenzene-1,2-diamine

생성물 1

HCID 178422326HCID 178422326, 화합물

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

반응 조건

온도
50 °C

실험 절차

A solution of 5-chloro-4-methyl-1,2-phenylenediamine (7.8 g) in a mixture of formic acid (35 mL) and hydrochloric acid (300 mL) was heated at 50° C. for 3 hours then treated with ammonium hydroxide solution until the solution was basic. The reaction mixture was then extracted with dichloromethane. The extracts were evaporated to give 6-chloro-5-methyl-1H-benzoimidazole (7 g).

후처리

  1. extractionThe reaction mixture was then extracted with dichloromethane
  2. customThe extracts were evaporated

출처 및 근거

ORD 기록
ord-268aecd43ad9496d950dfeba1e7333ae
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08288425B2

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