6-Chloroimidazo[2,1-b][1,3]thiazole-5-carbaldehyde → 6-Chloroimidazo[2,1-b][1,3]thiazole-5-carboxylic acid

HRID 2064749노트

반응식

HRID 2064749 반응식
[O-:1]Cl.[Na+].[Cl:4][C:5]1[N:6]=[C:7]2[N:11]([C:12]=1[CH:13]=[O:14])[CH:10]=[CH:9][S:8]2>O.C(O)(C)(C)C>[Cl:4][C:5]1[N:6]=[C:7]2[N:11]([C:12]=1[C:13]([OH:1])=[O:14])[CH:10]=[CH:9][S:8]2

참가 물질

5

반응물 2

HCID 3299506-Chloroimidazo[2,1-b][1,3]thiazole-5-carbaldehydeHCID 23665760Sodium Hypochlorite

생성물 1

HCID 3299776-Chloroimidazo[2,1-b][1,3]thiazole-5-carboxylic acid

시약·촉매·용매 2

HCID 962Water용매HCID 6386tert-Butanol용매

실험 절차

A solution of NaOCl (230 mmol) and NaH2PO4 (176 mmol) in water (195 mL) is added dropwise to a solution of 6-chloro-imidazo[2,1-b]thiazole-5-carbaldehyde (26.8 mmol) in tert.-butanol (195 mL) and the mixture is stirred for 8 h at RT. The solvents are partially removed in vacuo and the obtained precipitate is filtered off. The filtrate is made acidic and the obtained precipitate is filtered off to give the desired product as a white solid. LC-MS: tR=0.67 min; [M+H]+=202.9.

후처리

  1. customThe solvents are partially removed in vacuo
  2. filtrationthe obtained precipitate is filtered off
  3. filtrationthe obtained precipitate is filtered off

출처 및 근거

ORD 기록
ord-f8a3397c310d4681ac1b2a38b5f3b71a
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08288435B2

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