3-Hydroxyanthranilic Acid → 1,3-Benzoxazole-4-carboxylic acid

반응식

[NH2:1][C:2]1[C:10]([OH:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH:12](OC)(OC)OC>>[O:11]1[C:10]2=[CH:9][CH:8]=[CH:7][C:3]([C:4]([OH:6])=[O:5])=[C:2]2[N:1]=[CH:12]1

참가 물질

반응물 2

HCID 863-Hydroxyanthranilic Acid

HCID 9005Trimethyl orthoformate

생성물 1

HCID 183546021,3-Benzoxazole-4-carboxylic acid

실험 절차

A solution of 2-amino-3-hydroxy-benzoic acid (13.1 mmol) in trimethyl orthoformate (20.0 mL) is refluxed for 4 h, cooled to RT and concentrated in vacuo to give a crude product which is used without further purification. LC-MS: tR=0.66 min; [M+H]+=164.1.

후처리

concentrationconcentrated in vacuo

출처 및 근거

ORD 기록: ord-ba430ae285494c18bda18b0409b7e5f0
출처 데이터셋: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08288435B2

반응 노트

불러오는 중…