Water → 7-Benzothiazolecarboxylic acid

HRID 2064772노트

반응식

HRID 2064772 반응식
[OH-].[Na+].C[O:4][C:5]([C:7]1[C:15]2[S:14][CH:13]=[N:12][C:11]=2[CH:10]=[CH:9][CH:8]=1)=[O:6].C1COCC1.O>CO>[S:14]1[C:15]2[C:7]([C:5]([OH:6])=[O:4])=[CH:8][CH:9]=[CH:10][C:11]=2[N:12]=[CH:13]1

참가 물질

6

반응물 4

HCID 962WaterHCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 59316815Methyl benzo[d]thiazole-7-carboxylate

생성물 1

HCID 450769847-Benzothiazolecarboxylic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

At 0° C. an aqueous NaOH solution (50%, 6.0 mL) is added to a solution of benzothiazole-7-carboxylic acid methyl ester in a mixture of MeOH (39 mL), THF (11.7 mL) and water (3.0 mL). The mixture is stirred for 4 h and concentrated in vacuo. At 0° C. water (60 mL) is added and the mixture is made acidic (pH 5) by addition of conc. hydrochloric acid. After 30 min the precipitate is filtered off, washed with water and dried in vacuo to give the desired product. LC-MS: tR=0.77 min; [M+CH3CN+H]+=221.1.

후처리

  1. concentrationconcentrated in vacuo
  2. additionAt 0° C. water (60 mL) is added
  3. additionby addition of conc. hydrochloric acid
  4. filtrationAfter 30 min the precipitate is filtered off
  5. washwashed with water
  6. customdried in vacuo

출처 및 근거

ORD 기록
ord-b26896a7cede4bbaa32f6a3be9a762de
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08288435B2

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