Vorinostat → N-hydroxy-N'-phenyloctanediamide vorinostat

HRID 2064906

반응식

HRID 2064906 반응식
[CH:1]1[CH:2]=[CH:3][C:4]([NH:7][C:8]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([NH:18][OH:19])=[O:17])=[O:9])=[CH:5][CH:6]=1>C(O)C.O>[OH:19][NH:18][C:16](=[O:17])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][C:8]([NH:7][C:4]1[CH:3]=[CH:2][CH:1]=[CH:6][CH:5]=1)=[O:9].[CH:1]1[CH:6]=[CH:5][C:4]([NH:7][C:8]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([NH:18][OH:19])=[O:17])=[O:9])=[CH:3][CH:2]=1

참가 물질

3

반응물 1

HCID 5311Vorinostat

생성물 1

HCID 86620476N-hydroxy-N'-phenyloctanediamide vorinostat

시약·촉매·용매 1

HCID 19096565Water ethanol용매

반응 조건

온도
64 °C

실험 절차

The seed slurry is prepared by combining vorinostat—fine dry cake (97.8-116.3 g, 0.37-0.44 mol) and 50:50 (v/v) ethanol/water solution (1.0-1.2 L). Under a minimum of 15 psig pressure, the seed slurry is heated to 62-66° C., aged for about 0.5 hours and then cooled to 60-64° C.

후처리

  1. customThe seed slurry is prepared
  2. temperaturecooled to 60-64° C.

출처 및 근거

ORD 기록
ord-8abf0c6c44de43bab2ee6b1ad8691665
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08288440B2

연결된 노트

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