홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Hydrochloric Acid → 5-(3-Carbamoyl-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide

HRID 2065310
노트
인쇄 미리보기

반응식

HRID 2065310 반응식
[C:1]([C:4]1[O:8][C:7]([CH2:9][N:10]2[CH:14]=[C:13]([NH:15][C:16]([C:18]3[N:19]=[CH:20][O:21][C:22]=3[C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([C:29]#[N:30])[CH:24]=3)=[O:17])[CH:12]=[N:11]2)=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[NH4+].[OH-:32].Cl>S(=O)(=O)(O)O>[C:1]([C:4]1[O:8][C:7]([CH2:9][N:10]2[CH:14]=[C:13]([NH:15][C:16]([C:18]3[N:19]=[CH:20][O:21][C:22]=3[C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([C:29](=[O:32])[NH2:30])[CH:24]=3)=[O:17])[CH:12]=[N:11]2)=[CH:6][CH:5]=1)(=[O:3])[CH3:2]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14923Ammonium HydroxideHCID 669289435-(3-Cyano-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide

생성물 1

HCID 669286515-(3-Carbamoyl-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

5-(3-Cyano-phenyl)-oxazole-4-carboxylic acid [1-(5-acetyl-furan-2-ylmethyl)-1H-pyrazol-4-yl]-amide (50 mg, 0.112 mmol) in 97% sulfuric acid (0.17 mL) was stirred at rt overnight. The reaction mixture was then poured onto crushed ice, adjusted to pH 9 with NH4OH, and then strongly acidified with HCl 25%. The precipitate was filtered and washed with water until neutral pH. After drying, the title compound was obtained as a beige solid. LC-MS-conditions 02: tR=0.81 min; [M+H]+=420.12.

후처리

  1. additionThe reaction mixture was then poured
  2. customonto crushed ice
  3. filtrationThe precipitate was filtered
  4. washwashed with water until neutral pH
  5. customAfter drying

출처 및 근거

ORD 기록
ord-1c9b4c50121249889c7cea8444fcfef1
출처 데이터셋
uspto-grants-2012_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08288419B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트