Glycine → 2-(Carboxymethyl-amino)-6-chloro-quinoline-3-carboxylic acid

HRID 2065593

반응식

HRID 2065593 반응식
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[NH2:16][CH2:17][C:18]([OH:20])=[O:19]>>[C:18]([CH2:17][NH:16][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)([OH:20])=[O:19]

참가 물질

3

반응물 2

HCID 750GlycineHCID 242660682,6-Dichloroquinoline-3-carboxylic acid

생성물 1

HCID 673586802-(Carboxymethyl-amino)-6-chloro-quinoline-3-carboxylic acid수율 52%

실험 절차

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with glycine to provide the title compound in 52% yield as yellow needles (recrystallization from EtOH/water).

출처 및 근거

ORD 기록
ord-a0df76e0cc97404bb4d88e5753b5f061
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08288549B2

연결된 노트

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