Hydrochloric Acid → 2-Amino-3-[4-(quinolin-4-ylamino)-phenyl]propionic acid dihydrochloride dihydrate

HRID 2065673노트

반응식

HRID 2065673 반응식
[OH2:1].[NH2:2][CH:3]([CH2:7][C:8]1[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=1)[C:4]([OH:6])=[O:5].[Cl:15][C:16]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[N:19]=[CH:18][CH:17]=1.[ClH:26]>O1CCOCC1>[OH2:5].[OH2:1].[ClH:15].[ClH:26].[NH2:2][CH:3]([CH2:7][C:8]1[CH:9]=[CH:10][C:11]([NH:14][C:16]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[N:19]=[CH:18][CH:17]=2)=[CH:12][CH:13]=1)[C:4]([OH:6])=[O:5]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 691404-ChloroquinolineHCID 4587534-Amino-DL-phenylalanine hydrate

생성물 1

HCID 673602652-Amino-3-[4-(quinolin-4-ylamino)-phenyl]propionic acid dihydrochloride dihydrate수율 129.7%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

반응 조건

온도
120 °C

실험 절차

A mixture of 2-amino-3-(4-aminophenyl)-propionic acid hydrate (0.27 g, 1.5 mmol), 4-chloro-quinoline (0.245 g, 1.5 mmol) and conc. HCl (0.43 g) in dioxane (3 mL) is stirred at 120° C. temperature for 30 min in a tightly closed Pierce glass reaction vial. After cooling the liquid phase is separated and the solid residue is washed with acetonitrile (3×3 mL) and diethyl ether (5 mL) to give the title compound (0.405 g, 65%) as yellow solid.

후처리

  1. customin a tightly closed Pierce glass reaction vial
  2. temperatureAfter cooling the liquid phase
  3. customis separated
  4. washthe solid residue is washed with acetonitrile (3×3 mL) and diethyl ether (5 mL)

출처 및 근거

ORD 기록
ord-60b5088708854a399b33666dfb785d5b
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08288549B2

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