Acetic Acid → 2,6-Diisopropylphenyl acetate

HRID 2065981

반응식

HRID 2065981 반응식
FC(F)(F)C(OC(=O)C(F)(F)F)=O.[C:14]([OH:17])(=[O:16])[CH3:15].[CH:18]([C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([CH:27]([CH3:29])[CH3:28])[C:22]=1O)([CH3:20])[CH3:19]>O>[C:14]([O:17][C:22]1[C:21]([CH:18]([CH3:19])[CH3:20])=[CH:26][CH:25]=[CH:24][C:23]=1[CH:27]([CH3:29])[CH3:28])(=[O:16])[CH3:15]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 4943PropofolHCID 9845Trifluoroacetic anhydride

생성물 1

HCID 5960912,6-Diisopropylphenyl acetate수율 86%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
0 °C

실험 절차

3.45 g (16.4 mmol) of trifluoroacetic anhydride is added to 0.83 ml (14.6 mmol) of acetic acid at 0° C. while leaving the mixture to return to ambient temperature over 2 hours. The mixture is then cooled down to 0° C. and 1.95 g (11.0 mmol) of 2,6-diisopropylphenol is added dropwise. The reaction medium is maintained under stirring for 12 hours before being poured into ice-cooled water. After extraction with dichloromethane, the organic phase is washed with sodium chloride in a saturated aqueous solution before being dried over magnesium sulphate, filtered and concentrated under vacuum. A colourless oil is obtained with a yield of 86%. This product is sufficiently pure to be used directly in the following stage.

후처리

  1. customwhile leaving the mixture
  2. temperatureThe reaction medium is maintained
  3. additionbefore being poured into ice-
  4. extractionAfter extraction with dichloromethane
  5. washthe organic phase is washed with sodium chloride in a saturated aqueous solution
  6. dry with materialbefore being dried over magnesium sulphate
  7. filtrationfiltered
  8. concentrationconcentrated under vacuum
  9. customA colourless oil is obtained with a yield of 86%

출처 및 근거

ORD 기록
ord-c9ac66a01b0045e497c52de8b4afe73e
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08288560B2

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