Water → 3-(Piperidin-1-yl)phenol

HRID 2066391노트

반응식

HRID 2066391 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.C(=O)([O-])O.[Na+].Br[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]Br.O>C1(C)C=CC=CC=1.C(OCC)(=O)C>[N:1]1([C:2]2[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=2)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1

참가 물질

7

반응물 4

HCID 962WaterHCID 81001,5-DibromopentaneHCID 115683-AminophenolHCID 516892Sodium Bicarbonate

생성물 1

HCID 2298553-(Piperidin-1-yl)phenol

시약·촉매·용매 2

HCID 1140Toluene용매HCID 8857Ethyl Acetate용매

실험 절차

3-Aminophenol (500 mg) was dissolved in toluene (5.0 ml), the solution was added with sodium hydrogencarbonate (846.5 mg) and 1,5-dibromopentane (686.3 μl) at room temperature, and the mixture was stirred for 16 hours under reflux by heating. The reaction mixture was cooled, and then added with distilled water and ethyl acetate for extraction, and the organic layer was dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated under reduced pressure to obtain the title compound (513 mg).

후처리

  1. temperatureunder reflux
  2. temperatureby heating
  3. temperatureThe reaction mixture was cooled
  4. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
  5. filtrationfiltered
  6. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-1cde0ed98c63437e97ffc70cb0eaad3d
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08293715B2

반응 노트

불러오는 중…