1-Butanol → (2-Butoxy-2-oxoethyl)azanium chloride

HRID 2066567

반응식

HRID 2066567 반응식
Cl.[NH2:2][CH2:3][C:4]([OH:6])=[O:5].S(Cl)([Cl:9])=O.[CH2:11](O)[CH2:12][CH2:13][CH3:14]>>[Cl-:9].[CH2:11]([O:5][C:4](=[O:6])[CH2:3][NH3+:2])[CH2:12][CH2:13][CH3:14]

참가 물질

4

반응물 3

HCID 2631-ButanolHCID 22316Glycine HydrochlorideHCID 24386Thionyl Chloride

생성물 1

HCID 133112781(2-Butoxy-2-oxoethyl)azanium chloride

반응 조건

온도
70 °C

실험 절차

To a suspension of glycine hydrochloride (400 g, 3.58 mol) in n-butanol (8 L), thionyl chloride (1.37 L, 18.84 mol) was added slowly dropwise. After addition was complete, the reaction was heated at 70° C. overnight. The product mixture was concentrated under vacuum and the residue was triturated with a mixture of heptane/ethyl acetate. The white solid precipitated was filtered and dried under a stream of dry nitrogen to provide the title compound.

후처리

  1. additionwas added slowly dropwise
  2. additionAfter addition
  3. concentrationThe product mixture was concentrated under vacuum
  4. customthe residue was triturated with a mixture of heptane/ethyl acetate
  5. customThe white solid precipitated
  6. filtrationwas filtered
  7. customdried under a stream of dry nitrogen

출처 및 근거

ORD 기록
ord-d96b05922fea4a93990ebdf19d62dace
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08293731B2

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