Trimethylsilylacetylene → HCID 68421800, 화합물

HRID 2067219노트

반응식

HRID 2067219 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=2[F:16])[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([C:25]#[C:26][Si:27]([CH3:30])([CH3:29])[CH3:28])[CH:22]=[CH:21][C:20]=1C)=[O:18].BrC1C=CC(OC)=C([C:39](C2C=CC(NC3C=CC(F)=CC=3F)=CC=2Cl)=[O:40])C=1.C([Si](C)(C)C)#C>>[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=2[F:16])[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([C:25]#[C:26][Si:27]([CH3:30])([CH3:29])[CH3:28])[CH:22]=[CH:21][C:20]=1[O:40][CH3:39])=[O:18]

참가 물질

4

반응물 3

HCID 66111TrimethylsilylacetyleneHCID 67314552HCID 67314552, 화합물HCID 68417297(5-Bromo-2-methoxy-phenyl)-[2-chloro-4-(2,4-difluoro-phenylamino)-phenyl]-methanone

생성물 1

HCID 68421800HCID 68421800, 화합물

실험 절차

The reaction was carried out similarly as described in the preparation of compound 406, using compound 425 (0.99 mmol) and ethynyltrimethylsilane (0.99 mmol). The crude product was purified by continuous gradient flash chromatography using EtOAc/petroleum ether (40-60) 0:100 to 10:90 as the eluent to afford the title compound as light orange syrup.

후처리

  1. customThe crude product was purified by continuous gradient flash chromatography

출처 및 근거

ORD 기록
ord-2983d175c9a740c6ab988f3f97eda0f4
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08293772B2

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