Trimethylsilylacetylene → HCID 68418431, 화합물

HRID 2067226노트

반응식

HRID 2067226 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=2F)[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([C:25]#[C:26][Si:27]([CH3:30])([CH3:29])[CH3:28])[CH:22]=[CH:21][C:20]=1[CH3:31])=[O:18].ClC1C=C(NC2C=CC(F)=CC=2)C=CC=1C(C1C=C(I)C=CC=1C)=O.C([Si](C)(C)C)#C>>[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:10]=[CH:11][C:12]([F:15])=[CH:13][CH:14]=2)[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([C:25]#[C:26][Si:27]([CH3:28])([CH3:30])[CH3:29])[CH:22]=[CH:21][C:20]=1[CH3:31])=[O:18]

참가 물질

4

반응물 3

HCID 66111TrimethylsilylacetyleneHCID 67314552HCID 67314552, 화합물HCID 68421852[2-Chloro-4-(4-fluoro-phenylamino)-phenyl]-(5-iodo-2-methyl-phenyl)-methanone

생성물 1

HCID 68418431HCID 68418431, 화합물

실험 절차

The reaction was carried out similarly as described in the preparation of compound 406, using compound 430 (7.17 mmol) and ethynyltrimethylsilane (7.17 mmol). The crude product was purified by flash chromatography using EtOAc/petroleum ether (40-60) 1:8 as the eluent to afford the title compound as yellow solid.

후처리

  1. customThe crude product was purified by flash chromatography

출처 및 근거

ORD 기록
ord-16cd4c58670c4f8ba427ad94984154f5
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08293772B2

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