Ethanol → (Z)-2-Acetylamino-3-dimethylamino-but-2-enoic acid ethyl ester
반응식
[CH3:1][N:2]([CH3:12])/[C:3](=[C:5]1\[N:6]=[C:7]([CH3:11])[O:8][C:9]\1=[O:10])/[CH3:4].[H-].[Na+].[CH2:15]([OH:17])[CH3:16]>>[CH2:15]([O:17][C:9](=[O:10])/[C:5](/[NH:6][C:7](=[O:8])[CH3:11])=[C:3](/[N:2]([CH3:12])[CH3:1])\[CH3:4])[CH3:16]참가 물질
4
실험 절차
4-[1-Dimethylamino-eth-(Z)-ylidene]-2-methyl-4H-oxazol-5-one (7.4 g, 44.0 mmol) was dissolved in ethanol (50 ml), and sodium hydride (0.10 g, 4.4 mmol) was added at room temperature. The dark solution was refluxed for 1 h. The solvent was evaporated, and the crude product [MS: m/e=215.5 (M+H+)] was used without any further purification for the next step.
후처리
- temperatureThe dark solution was refluxed for 1 h
- customThe solvent was evaporated
- customthe crude product [MS: m/e=215.5 (M+H+)] was used without any further purification for the next step
출처 및 근거
- ORD 기록
- ord-81f953fea32e40dc8344c7bdb61e680a
- 출처 데이터셋
- uspto-grants-2012_10
- 특허 번호
- US08293916B2
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