Hydrochloric Acid → 1-(5-Bromo-pyridin-3-yl)-butylamine

반응식

[Br:1][C:2]1[CH:3]=[C:4]([CH:8]([NH:12]S(C(C)(C)C)=O)[CH2:9][CH2:10][CH3:11])[CH:5]=[N:6][CH:7]=1.Cl>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]([NH2:12])[CH2:9][CH2:10][CH3:11])[CH:5]=[N:6][CH:7]=1

참가 물질

반응물 2

HCID 313Hydrochloric Acid

HCID 584433932-Methyl-propane-2-sulfinic acid 1-(5-bromo-pyridin-3-yl)-butylamide

생성물 1

HCID 584433761-(5-Bromo-pyridin-3-yl)-butylamine수율 86.4%

실험 절차

2-Methyl-propane-2-sulfinic acid 1-(5-bromo-pyridin-3-yl)-butylamide (16 g, 48 mmol) is treated with aqueous HCl (3.0 N solution, 400 mL, 1.2 mol) at room temperature and stirred for 5 hours. The reaction mixture is quenched by addition of saturated aqueous sodium carbonate solution until pH 8 and extracted with dichloromethane (3×300 mL). The combined organic phases are dried over Na2SO4, filtered, and concentrated to afford 1-(5-bromo-pyridin-3-yl)-butylamine (9.5 g, 86%) of as a light brown oil.

후처리

customThe reaction mixture is quenched by addition of saturated aqueous sodium carbonate solution until pH 8
extractionextracted with dichloromethane (3×300 mL)
dry with materialThe combined organic phases are dried over Na2SO4
filtrationfiltered
concentrationconcentrated

출처 및 근거

ORD 기록: ord-a537609bc38f44a3875115e7ca624209
출처 데이터셋: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08293917B2

반응 노트

불러오는 중…