Hydrochloric Acid → (1-cyclohexyl-2-(5-(3-(methoxymethyl)phenyl)-1H-indazol-3-ylamino)-1H-benzo[d]imidazol-5-yl)methanol

HRID 2068293노트

반응식

HRID 2068293 반응식
[CH:1]1([N:7]2[C:11]3[CH:12]=[CH:13][C:14]([CH2:16][OH:17])=[CH:15][C:10]=3[N:9]=[C:8]2[NH:18][C:19]2[C:27]3[C:22](=[CH:23][CH:24]=[C:25]([C:28]4[CH:33]=[CH:32][CH:31]=[C:30]([CH2:34][O:35][CH3:36])[CH:29]=4)[CH:26]=3)[N:21](COCC[Si](C)(C)C)[N:20]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl>C(O)C>[CH:1]1([N:7]2[C:11]3[CH:12]=[CH:13][C:14]([CH2:16][OH:17])=[CH:15][C:10]=3[N:9]=[C:8]2[NH:18][C:19]2[C:27]3[C:22](=[CH:23][CH:24]=[C:25]([C:28]4[CH:33]=[CH:32][CH:31]=[C:30]([CH2:34][O:35][CH3:36])[CH:29]=4)[CH:26]=3)[NH:21][N:20]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 67253467(1-cyclohexyl-2-(5-(3-(methoxymethyl)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-ylamino)-1H-benzo[d]imidazol-5-yl)methanol

생성물 1

HCID 24798548(1-cyclohexyl-2-(5-(3-(methoxymethyl)phenyl)-1H-indazol-3-ylamino)-1H-benzo[d]imidazol-5-yl)methanol수율 26%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

In a 20 mL vial with septum cover was added {1-cyclohexyl-2-[5-(3-methoxymethyl-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazol-3-ylamino]-1H-benzoimidazol-5-yl}-methanol (58 mg, 0.000095 mol), ethanol (6.0 mL) and HCl (2.0 mL, 0.065 M). The mixture was refluxed for 1.5 hr. The mixture was concentrated and the residue dissolved in approx 1.5 mL of DMSO and purified by HPLC. The product fractions were lyopholized overnight to give 11.9 mg of the title compound as an off white solid.

후처리

  1. temperatureThe mixture was refluxed for 1.5 hr
  2. concentrationThe mixture was concentrated
  3. dissolutionthe residue dissolved in approx 1.5 mL of DMSO
  4. custompurified by HPLC

출처 및 근거

ORD 기록
ord-67d30d8955f643ebac3a69e0afba5200
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08293923B2

반응 노트

불러오는 중…