Butaclamol → Dopamine

HRID 2068454

반응식

HRID 2068454 반응식
C[N:2]1[CH2:12][C@H:11](C2C=CC=CC=2)[C:10]2[CH:9]=[C:8]([OH:19])[C:7](Cl)=[CH:6][C:5]=2CC1.CC([C@]1([OH:47])C[C@H]2N(C[C@H]3C4C2=CC=CC=4CCC2C=CC=CC3=2)CC1)(C)C>>[NH2:2][CH2:12][CH2:11][C:10]1[CH:5]=[CH:6][C:7]([OH:47])=[C:8]([OH:19])[CH:9]=1

참가 물질

3

반응물 2

HCID 37461ButaclamolHCID 3036864R-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol

생성물 1

HCID 681Dopamine

실험 절차

HEK cells were transfected with DNA encoding D1-NLS-GFP (2 micrograms), and D1-WT (6 micrograms) for 48 hours. These cells were treated 6 hrs after transfection with SCH-23390 (10 micromolar), or (+)butaclamol (10 micromolar). The medium containing antagonist was changed at 6, 22, 30 and 42 hours after transfection. Control cells received no antagonist treatment.

후처리

  1. additionThe medium containing antagonist
  2. customwas changed at 6, 22, 30 and 42 hours

출처 및 근거

ORD 기록
ord-5aa46aa9df904691aae8b1a8f824f6dc
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08298777B2

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