Lithium Hydroxide → 1-[(4-Ethoxybenzoyl)amino]cyclopropanecarboxylic acid

HRID 2068551노트

반응식

HRID 2068551 반응식
[CH2:1]([O:3][C:4]1[CH:20]=[CH:19][C:7]([C:8]([NH:10][C:11]2([C:14]([O:16]CC)=[O:15])[CH2:13][CH2:12]2)=[O:9])=[CH:6][CH:5]=1)[CH3:2].[OH-].[Li+]>O1CCOCC1.O>[CH2:1]([O:3][C:4]1[CH:5]=[CH:6][C:7]([C:8]([NH:10][C:11]2([C:14]([OH:16])=[O:15])[CH2:12][CH2:13]2)=[O:9])=[CH:19][CH:20]=1)[CH3:2]

참가 물질

5

반응물 2

HCID 3939Lithium HydroxideHCID 58304093Ethyl 1-[(4-ethoxybenzoyl)amino]cyclopropanecarboxylate

생성물 1

HCID 583041121-[(4-Ethoxybenzoyl)amino]cyclopropanecarboxylic acid수율 73.3%

시약·촉매·용매 2

HCID 962Water용매HCID 312751,4-Dioxane용매

실험 절차

Dissolve ethyl 1-[(4-ethoxybenzoyl)amino]cyclopropanecarboxylate (4.25 g, 15.33 mmol) in 1,4-dioxane (60 mL) and add lithium hydroxide (LiOH) (3.22 g, 76.63 mmol) dissolved in water (30 mL). Stir the reaction for approximately 16 hours at ambient temperature. Concentrate the mixture under reduced pressure, add water, acidify with 5N HCl, and collect the precipitate by filtration to give the title compound (2.8 g, 73%) as a white solid: MS (m/z): 248 (M+1).

후처리

  1. customthe reaction for approximately 16 hours at ambient temperature
  2. concentrationConcentrate the mixture under reduced pressure
  3. additionadd water
  4. customcollect the precipitate
  5. filtrationby filtration

출처 및 근거

ORD 기록
ord-11393c99d8094dba931f8a16b0bc4940
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08299061B2

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