참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 2-Acetamido-5-bromobenzoic Acid | HCID 520935 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 2-Amino-5-bromobenzoic acid | HCID 79858 | 91.7% |
반응 단계
To a mixture of 9 (71 g, 0.275 mol) in 1,4-dioxane (400 mL) was added HCl (400 mL). The mixture was refluxed for 4 h at 110° C. Then the mixture was concentrated and added to 300 mL water. The mixture was filtered and the pH was adjusted to 6 with 2N NaOH, washed with water and dried to give 10 as a white solid (54.5 g, yield: 91.7%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08299023B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_10 |
|---|
| ORD ID | ord-fa5d04b685f14e48a922b9a0d012d30c |
|---|
| 출처 메모 | uspto-grants-2012_10 |
|---|
