反应详情

温度

110 °C

To a mixture of 9 (71 g, 0.275 mol) in 1,4-dioxane (400 mL) was added HCl (400 mL). The mixture was refluxed for 4 h at 110° C. Then the mixture was concentrated and added to 300 mL water. The mixture was filtered and the pH was adjusted to 6 with 2N NaOH, washed with water and dried to give 10 as a white solid (54.5 g, yield: 91.7%).

1. concentrationThen the mixture was concentrated
2. additionadded to 300 mL water
3. filtrationThe mixture was filtered
4. washwashed with water
5. customdried