Benzyl Alcohol → 6-(Benzyloxy)-8-bromoisoquinoline

HRID 2069083노트

반응식

HRID 2069083 반응식
[CH2:1]([OH:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.CN(C(/N=N/C(N(C)C)=O)=O)C.[Br:40][C:41]1[CH:42]=[C:43](O)[CH:44]=[C:45]2[C:50]=1[CH:49]=[N:48][CH:47]=[CH:46]2>C1(C)C=CC=CC=1>[CH2:1]([O:8][C:43]1[CH:44]=[C:45]2[C:50](=[C:41]([Br:40])[CH:42]=1)[CH:49]=[N:48][CH:47]=[CH:46]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 244Benzyl AlcoholHCID 11776TriphenylphosphineHCID 5353800DiamideHCID 1357421998-Bromoisoquinolin-6-ol

생성물 1

HCID 674026996-(Benzyloxy)-8-bromoisoquinoline

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Benzyl alcohol (0.25 mL; Ald), triphenylphosphine (1.29 g), and TMAD (850 mg; Ald) were added to a toluene (30 mL) solution of Intermediate 7 (500 mg) and the resulting mixture was stirred at room temperature for 13 hours. The reaction mixture solution was filtrated, the solvent was evaporated under reduced pressure, and the residue was purified by column chromatography (Yamazen; n-hexane/ethyl acetate) to give the title compound (186 mg).

후처리

  1. filtrationThe reaction mixture solution was filtrated
  2. customthe solvent was evaporated under reduced pressure
  3. customthe residue was purified by column chromatography (Yamazen; n-hexane/ethyl acetate)

출처 및 근거

ORD 기록
ord-1873497c12c84a3685fd0a06d7ac0774
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08299055B2

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