2-Nitro-5-thiomorpholin-4-yl-4-trifluoromethyl-benzoic acid methyl ester → 2-Amino-5-thiomorpholin-4-yl-4-trifluoromethyl-benzoic acid methyl ester

HRID 2069270노트

반응식

HRID 2069270 반응식
[CH3:1][O:2][C:3](=[O:23])[C:4]1[CH:9]=[C:8]([N:10]2[CH2:15][CH2:14][S:13][CH2:12][CH2:11]2)[C:7]([C:16]([F:19])([F:18])[F:17])=[CH:6][C:5]=1[N+:20]([O-])=O>C(O)C.[Ni]>[CH3:1][O:2][C:3](=[O:23])[C:4]1[CH:9]=[C:8]([N:10]2[CH2:15][CH2:14][S:13][CH2:12][CH2:11]2)[C:7]([C:16]([F:17])([F:18])[F:19])=[CH:6][C:5]=1[NH2:20]

참가 물질

4

반응물 1

HCID 589645312-Nitro-5-thiomorpholin-4-yl-4-trifluoromethyl-benzoic acid methyl ester

생성물 1

HCID 589645242-Amino-5-thiomorpholin-4-yl-4-trifluoromethyl-benzoic acid methyl ester수율 84.9%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

실험 절차

300 mg of 2-nitro-5-thiomorpholin-4-yl-4-trifluoromethyl-benzoic acid methyl ester in 10 ml of dry ethanol are hydrogenated in presence of 60 mg of Raney nickel, After filtration of the catalyst the solution is evaporated to dryness yielding 233 mg of 2-amino-5-thiomorpholin-4-yl-4-trifluoromethyl-benzoic acid methyl ester as yellow powder, m.p. 85-117° C. (decomp.).

후처리

  1. filtrationAfter filtration of the catalyst the solution
  2. customis evaporated to dryness

출처 및 근거

ORD 기록
ord-991edd439a7e471bbb5257abb2cef030
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08299085B2

반응 노트

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