Ethyl Acrylate → HCID 68706213, 화합물

HRID 2069312노트

반응식

HRID 2069312 반응식
Br[C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)=[N:6][CH:7]=1.P.[CH2:16]([O:18][C:19](=[O:22])[CH:20]=[CH2:21])[CH3:17]>C([O-])(=O)C.[Pd+2].C([O-])(=O)C.C(N(CC)CC)C>[CH2:16]([O:18][C:19](=[O:22])[CH:20]=[CH:21][C:2]1[CH:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1)[CH3:17]

참가 물질

6

반응물 3

HCID 8821Ethyl AcrylateHCID 24404PhosphineHCID 221807795-Bromo-2-(4-fluorophenyl)pyridine

생성물 1

HCID 68706213HCID 68706213, 화합물

시약·촉매·용매 2

HCID 167845palladium(II) acetate촉매HCID 8471Triethylamine용매

반응 조건

온도
90 °C

실험 절차

9.30 g (36.9 mmol) of 5-bromo-2-(4-fluoro-phenyl)-pyridine were mixed with 100 ml of triethylamine, 2.06 g (9.2 mmol) of palladium acetate, 2.80 g (9.2 mmol) of tri)ortho-tolyl)phosphine and 6.47 g (64.6 mmol) of acrylic acid ethyl ester and heated to 90° C. for 2 h. The reaction mixture was evaporated, taken up in water and extracted with ethyl acetate. The combined organic phases were dried and evaporated, and the residue was subjected to column chromatography (silica gel, n-heptane/ethyl acetate 3:1). Yield: 7.7 g.

후처리

  1. customThe reaction mixture was evaporated
  2. extractionextracted with ethyl acetate
  3. customThe combined organic phases were dried
  4. customevaporated

출처 및 근거

ORD 기록
ord-d159d3ba97454be6a663c475ee9ec488
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08299102B2

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