Tetrahydrofuran → HCID 178459255, 화합물

HRID 2070081노트

반응식

HRID 2070081 반응식
[CH2:1]([O:4][C@H:5]1[CH2:10][CH2:9][C@H:8]([C:11]([O:13]CC)=[O:12])[CH2:7][CH2:6]1)[CH2:2][CH3:3].[OH-].[Na+].O1CCCC1>CO>[CH2:1]([O:4][C@H:5]1[CH2:10][CH2:9][C@H:8]([C:11]([OH:13])=[O:12])[CH2:7][CH2:6]1)[CH2:2][CH3:3]

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 178459257HCID 178459257, 화합물

생성물 1

HCID 178459255HCID 178459255, 화합물수율 45.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

cis/trans-Ethyl 4-(propyloxy)cyclohexanecarboxylate (D3) (39.1 g), 40% w/w sodium hydroxide solution (150 mL), tetrahydrofuran (200 mL) and methanol (150 mL) was stirred for approx. 72 hours. The solvent was partially removed then the resulting mixture was treated with ethyl acetate and water. The aqueous layer was separated, acidified with concentrated hydrochloric acid and extracted with diethyl ether. The ether layer was washed with brine, dried with anhydrous sodium sulphate and the solvent was removed to give the title compounds as oil (15.42 g).

후처리

  1. customThe solvent was partially removed
  2. additionthe resulting mixture was treated with ethyl acetate and water
  3. customThe aqueous layer was separated
  4. extractionextracted with diethyl ether
  5. washThe ether layer was washed with brine
  6. dry with materialdried with anhydrous sodium sulphate
  7. customthe solvent was removed

출처 및 근거

ORD 기록
ord-21bce44d914b4b1d8d22a654050d4a07
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08299257B2

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