Hydrochloric Acid → Ethanol hydrochloride

HRID 2070122노트

반응식

HRID 2070122 반응식
[ClH:1].[Br:2][C:3]1[CH:4]=[C:5]2[C:10](=[C:11]([N+:13]([O-:15])=[O:14])[CH:12]=1)[NH:9][C:8](=[O:16])[CH:7]([NH:17]C(=O)C)[CH2:6]2>C(O)C>[ClH:1].[CH2:8]([OH:16])[CH3:7].[ClH:1].[NH2:17][CH:7]1[CH2:6][C:5]2[C:10](=[C:11]([N+:13]([O-:15])=[O:14])[CH:12]=[C:3]([Br:2])[CH:4]=2)[NH:9][C:8]1=[O:16]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 59620398HCID 59620398, 화합물

생성물 2

HCID 21887872Ethanol hydrochlorideHCID 684113113-amino-6-bromo-8-nitro-3,4-dihydroquinolin-2(1H)-one hydrochloride

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Aqueous hydrochloric acid-ethanol solution was prepared (from commercial aqueous concentrated hydrochloric acid (3 L) and ethanol (6 L)), and N-(6-bromo-8-nitro-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)acetamide (known compound: Chem. Abst., 4150 (1947)) (604 g) was added to the solution, followed by heating for 14 hours under stirring and reflux. The reaction mixture was cooled on an ice bath, and the precipitates were recovered through filtration. The thus-obtained solid was washed with ethanol and dried, whereby the title compound (571 g) was yielded as a powdery compound.

후처리

  1. additionwas added to the solution
  2. temperatureby heating for 14 hours
  3. temperaturereflux
  4. temperatureThe reaction mixture was cooled on an ice bath
  5. filtrationthe precipitates were recovered through filtration
  6. washThe thus-obtained solid was washed with ethanol
  7. customdried

출처 및 근거

ORD 기록
ord-07bf1c12c6c1423da8740b2bdc360a4b
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08299255B2

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