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Hydrochloric Acid → HCID 59620347, 화합물

HRID 2070180
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HRID 2070180 반응식
[O:1]=[C:2]1[CH2:6][CH2:5][C:4](=[O:7])[N:3]1[C:8]1[CH:9]=[CH:10][CH:11]=[C:12]2[C:17]=1[N:16]([CH2:18][C:19]1[CH:23]=[CH:22][S:21][CH:20]=1)[C:15](=[O:24])[CH:14]([NH:25][C:26](=[O:46])[C@H:27]([NH:32][C:33](=[O:45])[C:34]([NH:37]C(=O)OC(C)(C)C)([CH3:36])[CH3:35])[CH2:28][CH:29]([CH3:31])[CH3:30])[CH2:13]2.Cl.C(=O)(O)[O-].[Na+]>C(OCC)(=O)C>[NH2:37][C:34]([CH3:35])([CH3:36])[C:33]([NH:32][C@H:27]([CH2:28][CH:29]([CH3:30])[CH3:31])[C:26]([NH:25][CH:14]1[CH2:13][C:12]2[C:17](=[C:8]([N:3]3[C:2](=[O:1])[CH2:6][CH2:5][C:4]3=[O:7])[CH:9]=[CH:10][CH:11]=2)[N:16]([CH2:18][C:19]2[CH:23]=[CH:22][S:21][CH:20]=2)[C:15]1=[O:24])=[O:46])=[O:45]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 59620355HCID 59620355, 화합물

생성물 1

HCID 59620347HCID 59620347, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매2회

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온도
50 °C

실험 절차

tert-Butyl 1-((2R)-1-(8-(2,5-dioxopyrrolidin-1-yl)-2-oxo-1-(thiophen-3-ylmethyl)-1,2,3,4-tetrahydroquinolin-3-ylamino)-4-methyl-1-oxopentan-2-ylamino)-2-methyl-1-oxopropan-2-ylcarbamate (30 mg) was added to ethyl acetate (0.3 mL), and 4N hydrochloric acid in ethyl acetate (230 μL) was added thereto, followed by stirring at 50° C. for six hours. Saturated aqueous sodium bicarbonate solution was added to the reaction mixture, and the mixture was extracted with ethyl acetate twice. The organic layers were combined, and the combined organic layer was dried over sodium sulfate. The solvent was evaporated under reduced pressure, whereby the title compound (17 mg) was yielded.

후처리

  1. additionwas added
  2. extractionthe mixture was extracted with ethyl acetate twice
  3. dry with materialthe combined organic layer was dried over sodium sulfate
  4. customThe solvent was evaporated under reduced pressure, whereby the title compound (17 mg)
  5. customwas yielded

출처 및 근거

ORD 기록
ord-9ae04607bf5f4bd5a382dbb619fa0310
출처 데이터셋
uspto-grants-2012_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08299255B2

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