1,3-Propanediamine, N1,N1,N3-trimethyl- → 4-(3,5-Dichloropyridin-4-ylamino)-8-(5-((3-(dimethylamino)propyl)(methyl)amino)pentyloxy)-7-methoxy-2H-chromen-2-one

HRID 20711

반응식

HRID 20711 반응식
[CH3:1][N:2]([CH3:8])[CH2:3][CH2:4][CH2:5][NH:6][CH3:7].Br[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][O:15][C:16]1[C:17]([O:36][CH3:37])=[CH:18][CH:19]=[C:20]2[C:25]=1[O:24][C:23](=[O:26])[CH:22]=[C:21]2[NH:27][C:28]1[C:33]([Cl:34])=[CH:32][N:31]=[CH:30][C:29]=1[Cl:35]>>[Cl:35][C:29]1[CH:30]=[N:31][CH:32]=[C:33]([Cl:34])[C:28]=1[NH:27][C:21]1[C:20]2[C:25](=[C:16]([O:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][N:6]([CH2:5][CH2:4][CH2:3][N:2]([CH3:8])[CH3:1])[CH3:7])[C:17]([O:36][CH3:37])=[CH:18][CH:19]=2)[O:24][C:23](=[O:26])[CH:22]=1

참가 물질

3

반응물 2

HCID 783021,3-Propanediamine, N1,N1,N3-trimethyl-HCID 248495698-(5-Bromopentyloxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2H-chromen-2-one

생성물 1

HCID 248493404-(3,5-Dichloropyridin-4-ylamino)-8-(5-((3-(dimethylamino)propyl)(methyl)amino)pentyloxy)-7-methoxy-2H-chromen-2-one

실험 절차

The title compound was prepared from N1,N1,N3-trimethylpropane-1,3-diamine and 8-(5-bromopentyloxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2H-chromen-2-one (Example 28) following the procedure outlined in Example 52. 1H NMR (400 MHz, DMSO-d6): δ 8.53 (s, 2H), 7.84 (d, 1H), 7.03 (d, 1H), 4.17 (br s, 1H), 3.96 (t, 2H), 3.87 (s, 3H), 2.54 (t, 4H), 2.45 (t, 2H), 2.31 (s, 3H), 2.27 (s, 6H), 1.69 (m, 2H), 1.64 (m, 2H), 1.56 (m, 2H), 1.47 (m, 2H); MS (ESI): 537.1.

출처 및 근거

ORD 기록
ord-9fce19a4c3b94dd29e06b7c1dcadedb2
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745646B2

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