Hydrochloric Acid → 3-(Methoxycarbonyl)-4-methylbenzoic acid
반응식
[CH:1]([C:3]1[CH:4]=[CH:5][C:6]([CH3:13])=[C:7]([CH:12]=1)[C:8]([O:10][CH3:11])=[O:9])=[O:2].[OH:14]OS([O-])=O.[K+].O.Cl>CN(C=O)C.CCOC(C)=O>[CH3:11][O:10][C:8]([C:7]1[CH:12]=[C:3]([CH:4]=[CH:5][C:6]=1[CH3:13])[C:1]([OH:14])=[O:2])=[O:9]참가 물질
7
실험 절차
A mixture of 268 mg of the methyl 5-formyl-2-methylbenzoate and 1.08 g (1.76 mmol) of Oxone in 6 mL of DMF was stirred at r.t. for 16.75 h. Water, 1N HCl, and EtOAc were added, and the aqueous layer was extracted with EtOAc. The combined extracts were dried over Na2SO4, filtered, and concentrated, and 3-(methoxycarbonyl)-4-methylbenzoic acid, which was used for the next reaction without further purification.
후처리
- extractionthe aqueous layer was extracted with EtOAc
- dry with materialThe combined extracts were dried over Na2SO4
- filtrationfiltered
- concentrationconcentrated
- custom3-(methoxycarbonyl)-4-methylbenzoic acid, which was used for the next reaction without further purification
출처 및 근거
- ORD 기록
- ord-430dedf4208244fc83ed6b0850c8dd3a
- 출처 데이터셋
- uspto-grants-2012_10
- 특허 번호
- US08299267B2
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