Brucine → HCID 18594875, 화합물

HRID 2071342노트

반응식

HRID 2071342 반응식
[N:1]([CH:4]([CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH2:5][CH2:6][C@@H:7]1[C@@H:11]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[C:10](=[O:23])[CH2:9][CH2:8]1)=[N+]=[N-].COC1C=C2[C@@]34[C@@H]5C[C@H]6C(CN5CC3)=CCO[C@H]3CC(=O)N([C@H]4[C@@H]63)C2=CC=1OC>[Pd]>[NH2:1][CH:4]([CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH2:5][CH2:6][C@@H:7]1[C@@H:11]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[C:10](=[O:23])[CH2:9][CH2:8]1

참가 물질

4

반응물 2

HCID 442021BrucineHCID 18594802HCID 18594802, 화합물

생성물 1

HCID 18594875HCID 18594875, 화합물

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

A 1.06 g. sample of ethyl 15-azido-9-oxo-prostanoate (Example 110) is hydrogenated using 100 mg. of 5% palladium on carbon in 50 ml. absolute alcohol for 16 hours. The filtration of the catalyst and evaporation of the solvent affords an oil. Silica gel chromatography gives 604 mg. of oil; λ max. 2.95, 6.30 (brucine) and 5.72 μ (carbonyl groups).

후처리

  1. filtrationThe filtration of the catalyst and evaporation of the solvent
  2. customaffords an oil
  3. customSilica gel chromatography gives 604 mg

출처 및 근거

ORD 기록
ord-f60c3c552dfc4ed5aa1086a1177ae164
출처 데이터셋
uspto-grants-1977_09
특허 번호
US04046787

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