Hydrochloric Acid → HCID 70637301, 화합물

HRID 2071346노트

반응식

HRID 2071346 반응식
[NH2:1][CH:2]([CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH2:3][CH2:4][C@@H:5]1[C@@H:9]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([O:18]CC)=[O:17])[C:8](=[O:21])[CH2:7][CH2:6]1.[OH-].[K+].[ClH:29].[Cl-].[Na+]>CO.O>[ClH:29].[NH2:1][CH:2]([CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH2:3][CH2:4][C@@H:5]1[C@@H:9]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])[C:8](=[O:21])[CH2:7][CH2:6]1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 5234Sodium ChlorideHCID 14797Potassium HydroxideHCID 18594875HCID 18594875, 화합물

생성물 1

HCID 70637301HCID 70637301, 화합물

시약·촉매·용매 1

HCID 22242641Methanol--water (1/1)용매

실험 절차

A solution of 1 g. of ethyl 15-amino-9-oxo-prostanoate (Example 143) in 15 ml. of methanol-water (1:1) containing 445 mg. of potassium hydroxide is stirred at ambient temperature for 18 hours. The solution is acidified with hydrochloric acid, saturated with sodium chloride, and extracted several times with methylene chloride. The organic phase is dried with anhydrous magnesium sulfate and taken to dryness to give a viscous oil; λ max. 2.80 - 3.70 (broad), 5.75, and 5.87 μ.

후처리

  1. extractionextracted several times with methylene chloride
  2. dry with materialThe organic phase is dried with anhydrous magnesium sulfate
  3. customto give a viscous oil

출처 및 근거

ORD 기록
ord-25f7f657e99748b78a6ef3bb48858ebe
출처 데이터셋
uspto-grants-1977_09
특허 번호
US04046787

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