Acetic Anhydride → Acetamide, N-[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]-

HRID 2072153노트

반응식

HRID 2072153 반응식
[C@@H:1]1([NH2:11])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>C1(C)C=CC=CC=1>[C@@H:1]1([NH:11][C:12](=[O:14])[CH3:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 70580741-Aminotetralin, (S)-

생성물 1

HCID 11412833Acetamide, N-[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]-

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

(S)-1,2,3,4-tetrahydro-1-naphthylamine (26.9 g.) is dissolved in 200 ml. of toluene and 36 g. of acetic anhydride is added while the temperature from the reaction exotherm is moderated at 50° C. to 60° C. with an ice-bath. The solution is heated to reflux for 0.5 hr. and then stirred at room temperature overnight. The mixture is then evaporated to dryness and the residue is washed well with ether. On drying, 26.1 g. of the title compound, m.p. 153° C. to 155° C., is obtained.

후처리

  1. customis moderated at 50° C. to 60° C. with an ice-bath
  2. temperatureThe solution is heated
  3. temperatureto reflux for 0.5 hr
  4. customThe mixture is then evaporated to dryness
  5. washthe residue is washed well with ether
  6. customOn drying

출처 및 근거

ORD 기록
ord-c54e3b09e0f6464aa4fa14ae972f4d38
출처 데이터셋
uspto-grants-1977_09
특허 번호
US04049717

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