Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 3-Methoxyestra-2,5(10)-dien-17beta-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Aluminum | HCID 5359268 | — |
| 반응물 | 3-Methoxyestra-1,3,5(10),8-tetraen-17beta-ol | HCID 11055206 | — |
| 반응물 | Lithium ethoxide | HCID 23661847 | — |
| 촉매 | Platinum | HCID 23939 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3-Methoxyestra-2,5(10)-dien-17beta-ol | HCID 101963 | — |
반응 단계
2.0 g. of 3-methoxy-1,3,5(10),8-estratetraen-17β-ol is electrolyzed in 200 ml. of liquid ammonia and 20 ml. of ethanol in the presence of 2 g. of lithium ethylate and 0.5 g. of lithium anilide for 3 hours in an undivided cell between an aluminum cathode and a platinum anode, with a current density of 2.5 A/cm2. After the reaction mixture has been worked up, 1.8 g. of 3-methoxy-2,5(10)-estradien-17β-ol is isolated, m.p. 110° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04050998 |
| 출처 데이터셋 | uspto-grants-1977_09 |
| ORD ID | ord-c8055da511c743a99c5b97a5b7660e3c |
| 출처 메모 | uspto-grants-1977_09 |