Formamide → 8-[(3,4-Dihydro-2-naphthalenyl)methyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

HRID 2072472노트

반응식

HRID 2072472 반응식
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][C:2]=1[CH2:11][N:12]1[CH2:20][CH2:19][C:15]([NH:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)([C:16]([NH2:18])=[O:17])[CH2:14][CH2:13]1.[CH:28](N)=O.C(OCC)(=O)C>O>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][C:2]=1[CH2:11][N:12]1[CH2:20][CH2:19][C:15]2([N:21]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:28][NH:18][C:16]2=[O:17])[CH2:14][CH2:13]1

참가 물질

5

반응물 3

HCID 713FormamideHCID 8857Ethyl AcetateHCID 214082231-[(3,4-Dihydro-2-naphthalenyl)methyl]-4-anilino isonipecotamide

생성물 1

HCID 214082128-[(3,4-Dihydro-2-naphthalenyl)methyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
170 °C

실험 절차

A mixture of 1-[(3,4-dihydro-2-naphthalenyl)methyl]-4-anilino isonipecotamide (5.0 g) and formamide (18 g) is heated for 12 hours at 170° C. The reaction mixture is cooled, diluted with water (100 ml), and extracted with chloroform. The chloroform solution is dried over sodium sulfate and concentrated to give crude product. Trituration with ethyl acetate produces the title compound.

후처리

  1. temperatureThe reaction mixture is cooled
  2. extractionextracted with chloroform
  3. dry with materialThe chloroform solution is dried over sodium sulfate
  4. concentrationconcentrated
  5. customto give crude product

출처 및 근거

ORD 기록
ord-9d18760453b047a1b98f888caa04b72a
출처 데이터셋
uspto-grants-1977_09
특허 번호
US04051248

반응 노트

불러오는 중…