3-Phenylphenol → Methyl(3-phenylphenoxy)acetate

HRID 2072581

반응식

HRID 2072581 반응식
[C:1]1([C:7]2[CH:8]=[C:9]([OH:13])[CH:10]=[CH:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH2:15][C:16]([O:18][CH3:19])=[O:17].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C.O>[C:1]1([C:7]2[CH:8]=[C:9]([CH:10]=[CH:11][CH:12]=2)[O:13][CH2:15][C:16]([O:18][CH3:19])=[O:17])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

6

반응물 3

HCID 113813-PhenylphenolHCID 11430Potassium CarbonateHCID 60984Methyl bromoacetate

생성물 1

HCID 13787157Methyl(3-phenylphenoxy)acetate

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

A mixture of 3-phenylphenol (5.00 g), methyl bromoacetate (3.1 ml) and potassium carbonate (8.1 g) in DMF was stirred at room temperature. After five hours, the reaction mixture was diluted with water (100 ml) and then extracted with ether. The combined organic layers were washed with aqueous sodium carbonate followed by brine and then dried, filtered and evaporated to give crude methyl (3-phenylphenoxy)acetate (7.2 g) as a pale yellow liquid, 1H NMR (CDCl3) delta 3.8 (3H,s), 4.7 (2H,s), 6.8-7.6 (9H,m) ppm.

후처리

  1. extractionextracted with ether
  2. washThe combined organic layers were washed with aqueous sodium carbonate
  3. customdried
  4. filtrationfiltered
  5. customevaporated

출처 및 근거

ORD 기록
ord-305bc901054e41edb770689a8a579347
출처 데이터셋
uspto-grants-1990_04
특허 번호
US04913721

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