Methyl iodide → 2-Bromo-4-(methylthio)aniline

HRID 2072590노트

반응식

HRID 2072590 반응식
[Br:1][C:2]1[CH:8]=[C:7]([S:9][C:10]#N)[CH:6]=[CH:5][C:3]=1[NH2:4].[C-]#N.[Na+].CI>CO>[Br:1][C:2]1[CH:8]=[C:7]([S:9][CH3:10])[CH:6]=[CH:5][C:3]=1[NH2:4]

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 8929Sodium Cyanide2회HCID 38124212-Bromo-4-thiocyanatoaniline

생성물 1

HCID 146018352-Bromo-4-(methylthio)aniline

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 2-bromo-4-thiocyanoaniline (11.5 g., 0.05 mole) and sodium cyanide (1.23 g., 0.025 mole) in methanol (100 ml.) is stirred at room temperature overnight. Sodium cyanide (0.025 mole) is then added and the reaction heated at reflux 2 hours and then cooled (0°-5° C.). Methyl iodide is added and stirring continued. Thin layer chromatography shows one product spot. Product is recovered by extraction with methylene chloride, 8.4 g.

후처리

  1. temperaturethe reaction heated
  2. temperatureat reflux 2 hours
  3. temperaturecooled (0°-5° C.)
  4. customProduct is recovered by extraction with methylene chloride, 8.4 g

출처 및 근거

ORD 기록
ord-17ab256e09fa46588c1f0b202f82a60e
출처 데이터셋
uspto-grants-1990_04
특허 번호
US04913728

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