Acetic Anhydride → 2-(2,4-Dichloro-benzoyl)-3-methoxyacrylonitrile

반응식

[Cl:1][C:2]1[CH:12]=[C:11]([Cl:13])[CH:10]=[CH:9][C:3]=1[C:4]([CH2:6][C:7]#[N:8])=[O:5].[C:14]([O:17][C:18](=O)C)(=O)C>>[Cl:1][C:2]1[CH:12]=[C:11]([Cl:13])[CH:10]=[CH:9][C:3]=1[C:4]([C:6](=[CH:14][O:17][CH3:18])[C:7]#[N:8])=[O:5]

참가 물질

반응물 2

HCID 7918Acetic Anhydride

HCID 136307283-(2,4-Dichlorophenyl)-3-oxopropanenitrile

생성물 1

HCID 537392442-(2,4-Dichloro-benzoyl)-3-methoxyacrylonitrile수율 104.5%

반응 조건

온도: 150 °C

실험 절차

A mixture of 8.8 g of 2,4-dichloro-benzoylacetonitrile, 69.2 g of methyl o-formate and 10.5 g of acetic anhydride is refluxed at a bath temperature of 150° C. for 3 hours. The volatile constituents are then distilled off in vacuo and finally under a fine vacuum at a bath temperature of 120° C. 11 g of 2-(2,4-dichloro-benzoyl)-3-methoxy-acrylonitrile are obtained as a viscous oil.

후처리

distillationThe volatile constituents are then distilled off in vacuo and finally under a fine vacuum at a bath temperature of 120° C

출처 및 근거

ORD 기록: ord-391df9ca579547fd8fe272604eefc0dd
출처 데이터셋: uspto-grants-1990_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04914228

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