HCID 14555476, 화합물 → (S)-1-Cbz-3-Aminopyrrolidine
반응식
[N:1]([C@H:4]1[CH2:8][CH2:7][N:6]([C:9]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:10])[CH2:5]1)=[N+]=[N-].[H][H]>CO.[Ni]>[NH2:1][C@H:4]1[CH2:8][CH2:7][N:6]([C:9]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:10])[CH2:5]1참가 물질
5
실험 절차
A solution of 14.7 g (60 mmol) of (S)-3-azido-1-pyrrolidinecarboxylic acid, phenylmethyl ester in 200 ml of methanol was treated with 1.0 g of Raney-nickel and shaken in a hydrogen atmosphere at pressures of 49.5-51 psi and temperatures of 25.3-29.5° for nine hours. The catalyst was removed by filtration and the solvent was removed in vacuo to give 13.2 g of the title compound.
후처리
- customThe catalyst was removed by filtration
- customthe solvent was removed in vacuo
출처 및 근거
- ORD 기록
- ord-8b2f28a8ca7546a98cfefefd9d3c87dd
- 출처 데이터셋
- uspto-grants-1990_04
- 특허 번호
- US04916141
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