Ethanol → HCID 19858041, 화합물

HRID 2073396노트

반응식

HRID 2073396 반응식
[CH3:1][C:2]1([CH3:24])[C:6](=[O:7])[O:5][C:4]2[CH:8]=[CH:9][C:10]3[C:15]([C:3]1=2)=[CH:14][C:13]([CH2:16][N:17]1[CH:21]=[N:20][CH:19]=[N:18]1)=[C:12]([C:22]#[N:23])[CH:11]=3.C(O)C.[BH4-].[Na+]>O>[OH:7][CH:6]1[O:5][C:4]2[CH:8]=[CH:9][C:10]3[C:15]([C:3]=2[C:2]1([CH3:24])[CH3:1])=[CH:14][C:13]([CH2:16][N:17]1[CH:21]=[N:20][CH:19]=[N:18]1)=[C:12]([C:22]#[N:23])[CH:11]=3

참가 물질

5

반응물 3

HCID 702EthanolHCID 4311764Sodium borohydrideHCID 54516723HCID 54516723, 화합물

생성물 1

HCID 19858041HCID 19858041, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 1,2-dihydro-1,1-dimethyl-2-oxo-8-(1H-1,2,4-triazol-1-ylmethyl)naphtho[2,1-b]furan-7-carbonitrile (0.07 g), ethanol (2 ml) and sodium borohydride (0.05 g) was stirred at room temperature for 18 h. Water (10 ml) was added, and the mixture was extracted with chloroform, and the extract was dried and evaporated to dryness under reduced pressure. The residue was recrystallised from ethyl acetate to give 1,2-dihydro-2-hydroxy-1,1-dimethyl-8-(1H-1,2,4-triazol-1-ylmethyl)naphtho[2,1-b]furan-7-carbonitrile, m.p. 219°-222°.

후처리

  1. extractionthe mixture was extracted with chloroform
  2. customthe extract was dried
  3. customevaporated to dryness under reduced pressure
  4. customThe residue was recrystallised from ethyl acetate

출처 및 근거

ORD 기록
ord-a6e6917a777848b0ad0154da5d361eb1
출처 데이터셋
uspto-grants-1990_04
특허 번호
US04916148

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