Diethyl Ether → 3-Bromo-1,1-bis(4-fluorophenyl)propane

HRID 2073481노트

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HRID 2073481 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[CH2:9][CH2:10]O)=[CH:4][CH:3]=1.P(Br)(Br)[Br:20].CCOCC>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[CH2:9][CH2:10][Br:20])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 24614Phosphorus tribromideHCID 197832883,3-Bis(4-fluorophenyl)propanol

생성물 1

HCID 138832773-Bromo-1,1-bis(4-fluorophenyl)propane

시약·촉매·용매 1

HCID 1140Toluene용매2회

반응 조건

온도
60 °C

실험 절차

50.1 g (0.202 mol) of 3,3-bis(4-fluorophenyl)propanol were dissolved in 150 ml of toluene, and a solution of 21.8 g (0.081 mol) of PBr3 in 50 ml of toluene was added dropwise. The mixture was stirred at room temperature for 30 minutes and at 60° C. for 90 minutes and, for hydrolysis, was poured onto 400 ml of ice, 200 ml of ether were added, the organic phase was separated off, washed with NaHCO3 solution and NaCl solution, dried and concentrated and the residue was distilled in vacuo for purification.

후처리

  1. additionwere added
  2. customthe organic phase was separated off
  3. washwashed with NaHCO3 solution and NaCl solution
  4. customdried
  5. concentrationconcentrated
  6. distillationthe residue was distilled in vacuo for purification

출처 및 근거

ORD 기록
ord-e191d02e21a043de9c13d75fe7081c88
출처 데이터셋
uspto-grants-1990_04
특허 번호
US04918073

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