Water → HCID 85585332, 화합물

HRID 2073516노트

반응식

HRID 2073516 반응식
S(O[CH2:12][CH2:13][O:14][C:15]1[CH:28]=[CH:27][C:18]([CH2:19][CH:20]2[S:24][C:23](=[O:25])[NH:22][C:21]2=[O:26])=[CH:17][CH:16]=1)(C1C=CC(C)=CC=1)(=O)=O.[N-:29]=[N+:30]=[N-:31].[Na+].O>CS(C)=O>[N:29]([CH2:12][CH2:13][O:14][C:15]1[CH:28]=[CH:27][C:18]([CH2:19][CH:20]2[S:24][C:23](=[O:25])[NH:22][C:21]2=[O:26])=[CH:17][CH:16]=1)=[N+:30]=[N-:31]

참가 물질

5

반응물 3

HCID 962WaterHCID 33557Sodium AzideHCID 86743861HCID 86743861, 화합물

생성물 1

HCID 85585332HCID 85585332, 화합물

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

To a solution of 5-[4-(2-Tosyloxyethoxy)Benzyl]-2,4-Thiazolidinedione (12.5 g) in dry Dimethylsulphoxide (80 ml) was added sodium azide (2 g) in one portion. The mixture was stirred at ambient temperature for 18 hours and the resulting solution added to water (250 ml). The aqueous solution was extracted with dichloromethane (2×300 ml) and the combined organic phases were washed with water (3×300 ml), dried (MgSO4), filtered and evaporated to give the title compound as an oil which was used in the next stage without further purification.

후처리

  1. extractionThe aqueous solution was extracted with dichloromethane (2×300 ml)
  2. washthe combined organic phases were washed with water (3×300 ml)
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. customevaporated

출처 및 근거

ORD 기록
ord-63d5d0bc5d734407b63fa7c7c825c973
출처 데이터셋
uspto-grants-1990_04
특허 번호
US04918091

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