Dimethylformamide → 1-[(3-Methylbutoxy)methyl]-3-nitrobenzene

HRID 2073680

반응식

HRID 2073680 반응식
[CH3:1][CH:2]([CH3:6])[CH2:3][CH2:4][OH:5].CN(C)C=O.Cl[CH2:13][C:14]1[CH:15]=[C:16]([N+:20]([O-:22])=[O:21])[CH:17]=[CH:18][CH:19]=1.[OH-].[K+]>O>[CH3:1][CH:2]([CH3:6])[CH2:3][CH2:4][O:5][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([N+:20]([O-:22])=[O:21])[CH:15]=1

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 12078alpha-Chloro-m-nitrotolueneHCID 14797Potassium HydroxideHCID 31260Isoamyl Alcohol

생성물 1

HCID 143301471-[(3-Methylbutoxy)methyl]-3-nitrobenzene

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Into a mixture of 500 ml (4.59 mol) of 3-methyl-1-butanol and 140 ml of dimethylformamide, 158.1 g (0.92 mol) of 3-chloromethylnitrobenzene was dissolved, and 78 g (1.39 mol) of potassium hydroxide pellets was added to the thus formed solution while cooling with water under a vigorous stirring. The temperature of the reaction mixture rised to 43° C. and then dropped slowly to room temperature. Thereafter, the reaction mixture was stirred for 7 hours at room temperature to complete the reaction.

후처리

  1. dissolutionwas dissolved
  2. customrised to 43° C.
  3. additiondropped slowly to room temperature
  4. customthe reaction

출처 및 근거

ORD 기록
ord-f1b386a450db4221819a68079da793cd
출처 데이터셋
uspto-grants-1990_04
특허 번호
US04919707

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