Ethanol → HCID 178487786, 화합물

HRID 2073775

반응식

HRID 2073775 반응식
Cl[C:2]1[C:11]([C:12]#[N:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7](OC)[CH:8]=2)[N:3]=1.[OH2:16].[NH2:17][NH2:18].[CH2:19](O)C>>[CH3:19][O:16][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]1[NH:17][N:18]=[C:12]([NH2:13])[C:11]1=[CH:10]2

참가 물질

4

반응물 3

HCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 8656122-Chloro-6-methoxyquinoline-3-carbonitrile

생성물 1

HCID 178487786HCID 178487786, 화합물

반응 조건

온도
0 °C

실험 절차

To a stirred suspension of 14.7 g 2-chloro-6-methoxy-3-quinolinecarbonitrile in 465 ml absolute ethanol was added 17 ml of hydrazine hydrate. The mixture was stirred at reflux for 24 hours and then cooled to 0° C. The resulting solid product was collected by filtration and boiled with 200 ml water to remove any hydrazine dihydrochloride present. The resulting material was filtered and dried in vacuo (90° C.), and recrystallized from 300 ml dimethylformamide to give 12.3 g 6-methoxy-1H-pyrazolo[3,4-b]quinolin-3-amine as a bright-yellow solid, m.p. >300° C.

후처리

  1. temperatureat reflux for 24 hours
  2. filtrationThe resulting solid product was collected by filtration
  3. customto remove any hydrazine dihydrochloride present
  4. filtrationThe resulting material was filtered
  5. customdried in vacuo (90° C.)
  6. customrecrystallized from 300 ml dimethylformamide

출처 및 근거

ORD 기록
ord-e856b0b942ca4b188d232eb02f3ec0a3
출처 데이터셋
uspto-grants-1990_04
특허 번호
US04920128

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