Hydrogen Bromide → HCID 14370125, 화합물
반응식
[C:1]([C:4]1[CH:5]=[C:6]([C:12]#[N:13])[C:7]([NH2:11])=[N:8][C:9]=1[CH3:10])(=[O:3])[CH3:2].[BrH:14].BrBr>C(O)(=O)C>[NH2:11][C:7]1[C:6]([C:12]#[N:13])=[CH:5][C:4]([C:1](=[O:3])[CH2:2][Br:14])=[C:9]([CH3:10])[N:8]=1참가 물질
5
반응 조건
- 온도
- 45 °C
실험 절차
2.7 g (15.4 mmol) of 5-acetyl-2-amino-3-cyano-6-methyl-pyridine are suspended in 110 ml of glacial acetic acid, and 1.9 ml (16.2 mmol) of 48% strength HBr are added. Then 5.2 g (32.4 mmol) of bromine are added, and the mixture is stirred at 45° C. for five hours. After cooling, the mixture is filtered with suction and the filter cake is stirred with NaHCO3 solution, filtered with suction and dried. Recrystallization from ethanol is used for purification.
후처리
- temperatureAfter cooling
- filtrationthe mixture is filtered with suction
- stirringthe filter cake is stirred with NaHCO3 solution
- filtrationfiltered with suction
- customdried
- customRecrystallization from ethanol
- customis used for purification
출처 및 근거
- ORD 기록
- ord-b9bb4e605f074ba1aab4a5319bc4f9bc
- 출처 데이터셋
- uspto-grants-1990_04
- 특허 번호
- US04920136
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