Potassium Carbonate → alpha-(3-(4-(2-Quinolinylmethyloxy)phenoxymethyl)phenoxy)acetonitrile

HRID 2074025노트

반응식

HRID 2074025 반응식
Cl[CH2:2][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][CH:12]=1)[O:6][CH2:7][C:8]#[N:9].[N:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][C:14]=1[CH2:23][O:24][C:25]1[CH:31]=[CH:30][C:28]([O-:29])=[CH:27][CH:26]=1.[Na+].C(=O)([O-])[O-].[K+].[K+]>CS(C)=O.O>[N:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][C:14]=1[CH2:23][O:24][C:25]1[CH:31]=[CH:30][C:28]([O:29][CH2:2][C:3]2[CH:4]=[C:5]([CH:10]=[CH:11][CH:12]=2)[O:6][CH2:7][C:8]#[N:9])=[CH:27][CH:26]=1

참가 물질

6

반응물 3

HCID 11430Potassium CarbonateHCID 14774148alpha-(3-Chloromethylphenoxy)acetonitrileHCID 23684421Sodium 4-(2-quinolinylmethyloxy)phenoxide

생성물 1

HCID 14774149alpha-(3-(4-(2-Quinolinylmethyloxy)phenoxymethyl)phenoxy)acetonitrile

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 962Water용매

실험 절차

A mixture of α-(3-chloromethylphenoxy)acetonitrile (0.025 mol), sodium 4-(2-quinolinylmethyloxy)phenoxide (0.025 mol) and anhydrous potassium carbonate (0.125 mol) in dimethylsulfoxide (50 ml) is stirred at ambient temperature for 18 hrs. The reaction is diluted with water (600 ml) and extracted with ethylacetate (3×150 ml). The ethyl acetate solution is washed with water (3×100 ml) and brine (100 ml) then dried and evaporated to give α-(3-(4-(2-quinolinylmethyloxy)phenoxymethyl)phenoxy)acetonitrile. (M.P. 110°-114° C.)

후처리

  1. extractionextracted with ethylacetate (3×150 ml)
  2. washThe ethyl acetate solution is washed with water (3×100 ml) and brine (100 ml)
  3. customthen dried
  4. customevaporated

출처 및 근거

ORD 기록
ord-80cbdb1bf2af4ab8976b7c0f718834f4
출처 데이터셋
uspto-grants-1990_04
특허 번호
US04920132

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