Triphenylphosphine → (3-Cyanobenzyl)triphenylphosphonium bromide

HRID 2074237노트

반응식

HRID 2074237 반응식
[C:1]1([P:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:20]([C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][CH:29]=1)[CH2:25][Br:26])#[N:21]>>[Br-:26].[C:20]([C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][CH:29]=1)[CH2:25][P+:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)#[N:21]

참가 물질

3

반응물 2

HCID 11776TriphenylphosphineHCID 97249Benzonitrile, 3-(bromomethyl)-

생성물 1

HCID 2778355(3-Cyanobenzyl)triphenylphosphonium bromide수율 72.7%

반응 조건

온도
80 °C

실험 절차

Triphenylphosphine (2.8 g) was added to a Tol (50 ml) solution of 3-cyanobenzyl bromide (2.0 g), followed by stirring at 80° C. for 5 hours. This was cooled to room temperature, and the precipitated solid was collected by filtration, and washed with Tol. This was dried under reduced pressure to obtain (3-cyanobenzyl)(triphenyl)phosphonium bromide (3.4 g).

후처리

  1. temperatureThis was cooled to room temperature
  2. filtrationthe precipitated solid was collected by filtration
  3. washwashed with Tol
  4. customThis was dried under reduced pressure

출처 및 근거

ORD 기록
ord-36f73407f0c34891ad33753396756501
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07919494B2

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