Propylamine → HCID 57869854, 화합물

HRID 20744노트

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HRID 20744 반응식
CO[C:3](=[O:13])[CH2:4][CH2:5][O:6][N:7]=[C:8]([O:10][CH2:11][CH3:12])[CH3:9].[CH2:14]([NH2:17])[CH2:15][CH3:16]>CO>[CH2:11]([O:10][C:8](=[N:7][O:6][CH2:5][CH2:4][C:3](=[O:13])[NH:17][CH2:14][CH2:15][CH3:16])[CH3:9])[CH3:12]

참가 물질

4

반응물 2

HCID 7852PropylamineHCID 71331645Methyl 3-{[(1-ethoxyethylidene)amino]oxy}propanoate

생성물 1

HCID 57869854HCID 57869854, 화합물수율 86%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
55 °C

실험 절차

To a known compound, 3-(1-ethoxy-ethylideneaminooxy)-propanoic acid methyl ester (CAS No. 97164-30-2, 300 mg, 1.585 mmol) were added methanol (3 ml) and n-propylamine (1.3 ml), and the mixture was stirred at 55° C. for 15 hours. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography to give N-(2-propylcarbamoyl-ethoxy)-acetimidic acid ethyl ester (296 mg, 86% yield).

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-cdbdab0d045348dd836917e4c0d1343b
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745663B2

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