Morpholine → 4-(2-Hydrazinyl-6-methyl-4-pyrimidinyl)morpholine

HRID 2074976노트

반응식

HRID 2074976 반응식
Cl[C:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4]([CH3:9])[N:3]=1.[NH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1.O.[NH2:17][NH2:18]>CO>[NH:17]([C:2]1[N:7]=[C:6]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[CH:5]=[C:4]([CH3:9])[N:3]=1)[NH2:18]

참가 물질

5

반응물 3

HCID 8083MorpholineHCID 24654Hydrazine hydrate (1:1)HCID 794712,4-Dichloro-6-methylpyrimidine

생성물 1

HCID 668584764-(2-Hydrazinyl-6-methyl-4-pyrimidinyl)morpholine수율 59.3%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 2,4-dichloro-6-methylpyrimidine (0.41 g, 2.50 mmol) in MeOH (5 mL) was added morpholine (0.5 mL, 5.73 mmol). The solution was stirred for 30 min at room temperature, and then hydrazine monohydrate (1.0 mL, 20.6 mmol) was added. The solution was then heated at 60° C. and stirred for 16 h. The solution was then cooled to room temperature and purified by reverse phase HPLC to afford 0.31 g of the title compound (59%) as a waxy white solid. MH+210.

후처리

  1. temperatureThe solution was then heated at 60° C.
  2. stirringstirred for 16 h
  3. temperatureThe solution was then cooled to room temperature
  4. custompurified by reverse phase HPLC

출처 및 근거

ORD 기록
ord-da1608fe464742fc891b2316e834ad4b
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07919528B2

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