Methyl iodide → 5-tert-Butyl-2-methoxy-1-methyl-3-nitro-benzene

HRID 2075577노트

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HRID 2075577 반응식
[C:1]([C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8]([OH:14])=[C:7]([CH3:15])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[C:16]([O-])([O-])=O.[K+].[K+].CI>CC(C)=O>[C:1]([C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8]([O:14][CH3:16])=[C:7]([CH3:15])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 574185474-tert-Butyl-2-methyl-6-nitro-phenol

생성물 1

HCID 213537455-tert-Butyl-2-methoxy-1-methyl-3-nitro-benzene수율 99%

시약·촉매·용매 1

HCID 180Acetone용매

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온도
60 °C

실험 절차

4-tert-Butyl-2-methyl-6-nitro-phenol (209 mg, 1 mmol) was dissolved in 3 mL acetone. 552 mg K2CO3 (4 eq) was added, followed by addition of MeI (0.33 mL, 5 mmol). The reaction mixture was stirred vigorously at 60° C. overnight. After removal of the acetone, the residue was shaken with DCM. Filtration and evaporation of the solution yielded 221 mg product which was used as such.

후처리

  1. customAfter removal of the acetone
  2. stirringthe residue was shaken with DCM
  3. filtrationFiltration and evaporation of the solution

출처 및 근거

ORD 기록
ord-ec3389d054144c86b2772a7beeb7aa87
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07919617B2

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