Chloroacetaldehyde → 4-[3-(5-Phenyl-imidazo[1,2-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-ol

HRID 2075665노트

반응식

HRID 2075665 반응식
[NH2:1][C:2]1[CH:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][C:6]([S:18][C:19]3[CH:20]=[C:21]([C:25]4(C#N)[CH2:30][CH2:29][O:28][CH2:27][CH2:26]4)[CH:22]=[CH:23][CH:24]=3)=[CH:7][CH:8]=2)[N:3]=1.Cl[CH2:34][CH:35]=O.[O:37]1CCOCC1>O.C([O-])(O)=O.[Na+]>[C:12]1([C:10]2[C:9]3[C:4](=[CH:5][C:6]([S:18][C:19]4[CH:20]=[C:21]([C:25]5([OH:37])[CH2:30][CH2:29][O:28][CH2:27][CH2:26]5)[CH:22]=[CH:23][CH:24]=4)=[CH:7][CH:8]=3)[N:3]3[CH:34]=[CH:35][N:1]=[C:2]3[CH:11]=2)[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

참가 물질

6

반응물 3

HCID 33ChloroacetaldehydeHCID 312751,4-DioxaneHCID 670910914-[3-(2-Amino-4-phenyl-quinolin-7-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-carbonitrile

생성물 1

HCID 248757664-[3-(5-Phenyl-imidazo[1,2-a]quinolin-8-ylsulfanyl)-phenyl]-tetrahydro-pyran-4-ol

시약·촉매·용매 2

HCID 516892Sodium Bicarbonate촉매HCID 962Water용매

반응 조건

온도
70 °C

실험 절차

To 1t (78 mg, 0.18 mmol) in 1,4-dioxane (3 mL) and water (1 mL) was added chloroacetaldehyde (50 wt %, 0.04 mL, 0.27 mmol) and saturated aqueous NaHCO3 (2 drops), and the reaction was heated to 70° C. until no starting material was seen by tlc analysis. The mixture was concentrated and purified by preparative HPLC to give the desired product, 1u.

후처리

  1. concentrationThe mixture was concentrated
  2. custompurified by preparative HPLC

출처 및 근거

ORD 기록
ord-9cedc9dd10ab4bbcbe56d69391f3d249
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07919621B2

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