Bromine → 2-Bromo-6-(2-methoxy-phenyl)-cyclohexanone

HRID 2075986노트

반응식

HRID 2075986 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C:10]1=[O:15].[Br:16]Br>C(Cl)(Cl)Cl>[Br:16][CH:11]1[CH2:12][CH2:13][CH2:14][CH:9]([C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[O:2][CH3:1])[C:10]1=[O:15]

참가 물질

4

반응물 2

HCID 24408BromineHCID 282984Cyclohexanone,2-(2-methoxyphenyl)-

생성물 1

HCID 670958932-Bromo-6-(2-methoxy-phenyl)-cyclohexanone수율 64.1%

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

2-(2-Methoxy-phenyl)-cyclohexanone (51 mg, 0.27 mmol) was dissolved in chloroform (1 mL). To this solution bromine (45.4 mg, 0.28 mmol) in chloroform (0.5 mL) was added drop wise at room temperature. The reaction was stirred for 3 hours at room temperature and the solvent was removed under reduced pressure to yield the crude title compound (49 mg) which was used directly in the next step without further purification.

후처리

  1. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-dfb7577146224dbeacf490966ca91a7a
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07923450B2

반응 노트

불러오는 중…